Seminar Details
2009-11-17 (14.00) : A Systems Biology Approach to Apoptosis Signalling
At Euler building
Organized by Mathematical Engineering
Speaker :
Eric
BULLINGER (ULg)
Abstract :
Apoptosis is an important physiological process crucially involved in
the development and homeostasis of multi-cellular organisms. Although
the major signalling pathways leading from the extrinsic induction to
the execution of apoptosis have been unravelled, a detailed mechanistic
understanding of the complex underlying network and the signal crosstalk
remains elusive. A systems biology approach allows to combine diverse
data into mathematical models to perform predictive simulations and
testing of quantitative and dynamical hypotheses. The modelling process
furthermore reveals theoretical and computational challenges.